I happen to touch that area for HSEARCH-668.
Matt, so the initializeJMSQueueConnectionFactory passes but the initializeJMSQueue fails?
It's interesting as both do a JNDI lookup on JMS-ish things.

In the TX code for HSEARCH-668, we do delay the queue and connection lookup to just in time and we do them each time. I was wondering about the perf cost but that might solve your problem.