It would be nice to have an easy way to set the reference endpoint at runtime for every call.
Use cases:

• To allow to configure different endpoint per environment, so there is no need to recompile the application or use System.property to set endpoints.
• To allow a service to invoke different endpoints depending on a "logic" in a component.
• To provide with greater flexibility on service creation.

For this, an option could be to provide hook points in the OutboundHandler so the endpoint for the ServiceReference that has been set-up through the configuration can be obtained from some other place.

E.g:

 String toAddress = SOAPUtil.getToAddress(exchange.getContext());  
 if (address == null){ // This means there is no Addressing, so endpoint can be overwritten if configured  
    toAddress = InjectAddressFromCache(); // Probably with a hook point could be better, to be able to set toAddress depending on ServiceName or whatever  
 }  
 if (toAddress != null) {  
      _dispatcher.getRequestContext().put(BindingProvider.ENDPOINT_ADDRESS_PROPERTY, toAddress);  
 }