I don't think you can. You can try posting on the JBoss Cache user forum and see if someone has a clever suggestion. Only thing that comes to mind for me is subclassing JDBCCacheLoader and FileCacheLoader such that they take a configuration attribute that defines the region they apply to. Then use JBC's chaining cache loader functionality[1] to deploy multiple cache loaders, each configured for a different region. But I don't know whether that would really work in practice or whether there would be insurmountable gotchas. [1] http://www.jboss.org/file-access/default/members/jbosscache/freezone/docs... View the original post : http://www.jboss.org/index.html?module=bb&op=viewtopic&p=4225197#... Reply to the post : http://www.jboss.org/index.html?module=bb&op=posting&mode=reply&a...