There's no out of the box support for this, I'm afraid. One way to approach it is to create a delegating cache loader, that can be configured to only handle a given region (children of a given fqn). Then this new cache loader can be used to wrap the actual cache loaders you want to use, and make each one of them take care of a single region. Take a look at how ReadOnlyDelegatingCacheLoader is implemented, you need something similar. View the original post : http://www.jboss.org/index.html?module=bb&op=viewtopic&p=4241384#... Reply to the post : http://www.jboss.org/index.html?module=bb&op=posting&mode=reply&a...